Basic and clinical pharmacology

B.3.7- Basic and clinical pharmacology

Course Name

Code

Semester

Theory
(hours/week)

Application
(hours/week)

Credit

ECTS

Basic and clinical pharmacology

B.3.7

5th

3

1

4

4

Prequisites General chemistry, biochemistry, anatomy, normal physiology, microbiology
Course language English
Course type Must 
Mode of Delivery Face-to-Face 
Learning and teaching strategies Lecture
Discussion
Question and Answer
Instructor (s) Professor Dr. Osman Gokalp
Course objective

To know the desired and undesirable effects of drugs in the treatment of diseases. We aim to individualize treatments according to each patient. By taking briefly the history of drug development, we aim to make new treatments possible in the light of their experiences so that they can use pharmacology information in the effective treatment applications with the least unwanted effect from the smallest to the largest. We aim to use pharmacology principles in providing diagnosis, treatment and preventive services to patients. In addition, while providing services such as consultancy, education and research, we also aim to practice basic and clinical pharmacology knowledge. Knowing that the drug may be a double-sided knife, we aim to stay away from any practical applications such as polypharmacy and to live in principle as a principle. We aim to do business in common. We aim to gain the distinction of being a multi-lingual physician in order to reach more information in the world.

Learning outcomes
  1. To learn general information and concepts about pharmacology and molecular pharmacology, to learn about the target molecules of the drugs, ion channels, enzymes,

  2. to know the molecules of molecules, molecular models in drug-receptor interaction and radioligand binding methods.

  3. to have knowledge about the mechanisms of action of intracellular molecules or drugs that target cell components, to understand and interpret drugs or treatment modalities that play a role in physiological and / or pathological processes, which molecular structures and / or which molecular processes are effective in treatment or prophylaxis, gain the skill of evaluation and systematically transfer what they have learned.

Course Content

This course is designed mainly for medical students to understand the medical pharmacology that it covers general pharmacology, cardiovascular pharmacology,neuronal pharmacology, chemotherapeutics, gastro intestinal pharmacolology, endocrin pharmacology and urogenıtal pharmacology, and autonomic pharmacology.

In order to foster a student’s ability to analyze and solve problems in their future clinical career, the course will provide the conceptual basis for understanding pathophisiology and particularly address the fundamental mechanisms of their pathogenicity. It will also provide opportunities for a student to develop both informatic and diagnostic skills in pharmacology, including the practical application and interpretation of laboratory tests for the treatment of diseases.

The faculty also wish to instill in students the love for learning, the ability to think for themselves, the desire to use knowledge creatively for the benefit of all people, and the appreciation of the beauty found in the natural world that we all share. This course is also being aimed developing students’ self-learning skills in the field for their obligations as life-long learning and engender the idea of teamwork as a necessary element of the conduct of modern medicine.

References

Basic and Clinical Pharmacology 14E by Bertram Katzung; Anthony Trevor

Goodman and Gilman’s the Pharmacological Basis of Therapeutics, 13th Edition by Randa Hilal-Dandan; Bjorn Knollman; Laurence Brunton

Lippincott Pharmacology Lippincott’s Illustrated Reviews: Pharmacology

Lange Pharmacology Rang & Dale’s Pharmacology, 8th Edition (Latest Edition)

Katzung Pharmacology Katzung Basic & Clinical Pharmacology 13 th edition 2015 

Basic and Clinical Pharmacology, ed.14 by Bertram G. Katzung; Anthony J. Trevor

Course outline weekly

Weeks

Topics

Week 1 Introduction to Pharmacology

Pharmacokinetics; Drugs of Membrane Permeation and Absorption

Distribution of Drugs in Body

Biotransformation of Drugs

Week 2 Elimination of Drugs

The Way of Drug Use and Pharmaceutical Forms

Pharmacodynamics; Quantitative and Quantal Dosage-Response Curves

Signal Mechanisms

Week 3 Factors Altering Drugs Effects

Drug-Drug and Drug-Food Interactions

Overview of Toxic Effects of Drugs

Week 4 Drugs Used in the Treatment of Anemia

Pharmacovigilance: Drug Safety Monitoring

Pharmacovigilance Practice

Week 5 Drug Development and Testing

Toxicology; Theraphy of Poisinoning

Immunomodulators

Week 6 Mid term
Week 7 Antineoplastic Drugs
Week 8 Antibacterial Agents

Inhibitors of Cell-Wall Synthesis

Inhibitors of Bacterial Protein Synthesis

Week 9 Inhibitors of Nucleic Acid Synthesis

Antitubercular Drugs

Antiprotozoal and Antimalarial Drugs

Anthelmintic Drugs

Week 10 Antiviral Drugs

Antifungal Drugs

Antiseptics and Disinfectants

Week 11 Drugs Used to Treat Peptic Ulcer

Antiemetics and Antidiarrhoeals

Week 12

Mid term

Week 12 Laxative and Purgative Drugs

Drugs Related to Hypothalamic and Pituitary Hormones

Glucocorticoids

Drugs Used in Obesity

Week 14 Drugs Used for Bone and Mineral Disorders

Antithyroid Agents

Drugs Used in Diabetes

Steroid Hormones

Week 15 Androgens Anabolic Steroids and Antiandrogens

Oxytocic Drugs

Pharmacogenetics

Week 16 Drug Use During Pregnancy and Teratogenicity

Calciotropic Drugs, capsules, etc., and their related with clinic practice.

Week 17 Mid term
Week 18 Final exam

Assesment methods

Course activities

Number

Percentage

Attendance

1

10

Laboratory

0

0

Application

0

0

Field activities

0

0

Specific practical training (Interactive case study and answer the questions practically)

1

20

Assignments

0

0

Presentation

0

0

Project

0

0

Seminar

0

0

Midterms

3

70

Total

100

Percentage of semester activities contributing grade succes

0

60

Percentage of final exam contributing grade succes

0

40

Total

100

WORKLOAD AND ECTS CALCULATION

Activities

Number

Duration (hour)

Total Work Load

Course Duration (x16)

32

2

64

Laboratory

0

0

0

Application

0

0

0

Specific practical training (Interactive case study and answer the questions practically)

4

5

20

Field activities

0

0

0

Study Hours Out of Class (Preliminary work, reinforcement, ect)

16

2

32

Presentation / Seminar Preparation

0

0

0

Project

0

0

0

Homework assignment

0

0

0

Midterms (Study duration)

1

2

2

Final Exam (Study duration)

1

2

2

Total Workload

120

Matrix Of The Course Learning Outcomes Versus Program Outcomes

D.9. Key Learning Outcomes Contrubition level*
1 2 3 4 5

Explains the basic structure, development and physiological functioning of the body at the level of molecules, cells, tissues, organs and systems.

X

Defines the causes of diseases, mechanisms of occurrence and changes in affected organs with information based on scientific data.

X

Evaluates and applies the principles of diagnosis, treatment, prevention and rehabilitation of diseases and epidemiology and reduction of common diseases in the community.

 X

Evaluate national and international health systems in the context of health policies, finance and administration.

 X

Know the research processes that constitute the basis of medical knowledge and have the knowledge of foreign language to follow the developments in this field.

 X

Takes a medical history from the patient and, if necessary, from his relatives.

 X

Performs physical examination of patients, evaluates clinical, laboratory and radiological and findings of common diseases and applies diagnosis and treatment processes using appropriate process steps.

 X

Recognizes life-threatening situations, makes appropriate first treatment and directs when necessary.

 X

Performs preventive medical services.

 X

Keeps medical and forensic records in accordance with legal regulations, gives importance to the confidentiality of patient information and prepares and presents patient information when necessary.

X

Plans and performs the processes for the prevention and health promotion in the context of individuals and community.

 X

Gain the competency to work independently and take responsibility in compulsory situations.

 X

Demonstrate a lifelong learning behavior towards professional and social changes.

X

Fulfills his responsibilities as within the framework of professional values, ethical principles and legislations without discriminating on the basis of race, gender, religion, social and cultural.

X 

Takes part in the teamwork with his colleagues and health care workers for the disease prevention and health promotion.

X

Follow the scientific and technological developments in medical practice.

X

*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest