Pathophysiology

B3.9-Pathophysiology

CourseName

Code

Semester

Theory
(hours/week)

Application
(hours/week)

Credit

ECTS

Pathophysiology

B3.9

5

3

1

4

4

Prequisites Normal physiology, anatomy, biochemistry.
Course language
English
Course type Must 
Mode of Delivery Face-to-Face 
Learning and teaching strategies Lecture
Discussion
Question and Answer
Instructor (s) Gulira Kamal kyzy
Course objective Study of the pathology of diseases and injuries across the life span. Topics include etiology, symptoms, and the physical and psychological reactions to diseases and injuries.
Learning outcomes

1. Distinguish environmental factors, physical, psychosocial, and cognitive characteristics of various diseases and conditions.

2. Identify implications of therapeutic interventions for diseases and conditions.

3. Demonstrate a basic understanding of the concepts and elements of disease.

4. Demonstrate an understanding of the mechanisms of diseases, the diagnosis of diseases, and the treatment of diseases.

5. Understand the pharmacological treatment of diseases or conditions.

6. Discuss common laboratory and diagnostic tests.

Course Content The purpose of this course is to provide students with a basic understanding of factors that contribute to the occurrence of various diseases, mechanisms of disease development, human organism reaction to diseases, clinical signs and symptoms and how those diseases may be treated. Students will learn how to recognize mechanisms of disease development, risk factors and the signs and symptoms of diseases that may be found in a health record.
References

Pathoma Lecture Notes.2017

Text Book of Pathology – 6th ed. 2010

Textbook of Medical Physiology – 11th edition, 2005

Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/

Uptodate: https://www.uptodate.com/home

Course outline weekly

Weeks

Topics

Week 1 Introduction. The subject and tasks of pathophysiology. Basic concepts of general nosology.

The concept of «norm», «health», «illness». General etiology and pathogenesis.

Week 2 Growth Adaptations, Cellular injury and Cell Death. Amyloidosis.
Week 3 Inflammation, Inflammatory Disorders, and Wound Healing. Acute inflammation.
Week 4 Hemostasis and Related Disorders. Primary and secondary hemostasis

Hemostasis diseases: hypocoagulobility, hypercoagulability: Idiopathic thrombocytopenic purpura (ITP). Hemophilia A. Hemophilia B. Von Willebrand disease. Anemia

Week 5 White Blood cell disorders.

Leukopenia and Leukocytosis. Infectious Mononucleosis.

Week 6 Module week
Week 7 Gastrointestinal Pathology: oral cavity, salivary gland, esophagus: Gastroesophageal reflux disease (GERD), Barret’s esophagus. Stomach: Acute and chronic gastritis, Peptic ulcer disease.
Week 8 Small Bowel: Inflammatory Bowel Disease (IBD): Ulcerative colitis vs Chorn disease. Colon: Hirschprung disease
Week 9 Kidney and Urinary Tract Pathology. Acute renal failure: Pre-renal azotemia, Intra-renal azotemia, Post-renal azotemia.
Week 10

Nephrotic Syndrome: membranous nephropathy, membranoproliferative glomerulonephritis.

Nephritic Syndrome: post- streptococcus glomerulonephrits, Rapidly progressive glomerulonephritis (RPGN), Goodpasture syndrome

Week 11 Midterm
Week 12 Pathology of endocrine system: Anterior and posterior pituitary gland. Nonfunctional and functional tumors of anterior Pituitary. Hypopituitarism.
Week 13 Adrenal glands: Adrenal cortex. Medulla. Disorders of adrenal cortex: Addison disease, Cushing’s syndrome. Hyperaldesteronism. Medulla disorders. Pheochromocytoma.
Week 14 Thyroid gland: Thyroxine. Triiodthyronine. Hyperthyroidism (thyrotoxicosis). Grave’s diseases. Hypothyroidism. Cretinism. Mixedema.
Week 15 Thyroiditis. Hashimoto’s disease. Parathyroid glands. Vitamin D. PTH hormone. Primary hyperparathyroidism. Secondary hyperparathyroidism. Hypoparathyroidism. Pseudohypoparathyroidism.
Week 16 Endocrine Pancreas. Type 1 diabetus mellitus. Type 2 diabetus mellitus. Pancreatic endocrine tumor. Gonads. Steroid hormones: Testosterone. Estrogen and Progesterone.
Week 17 Midterm
Week 18 Final exam

Assesment methods

Course activities

Number

Percentage

Attendance 1 10
Laboratory 0 0
Application 0 0
Field activities 0 0
Specific practical training 0 0
Assignments 2 20
Presentation 0 0
Project 0 0
Seminar 0 0
Midterms 3 70

Total

100

Percentage of semester activities contributing grade success 0 60
Percentage of final exam contributing grade success 0 40

Total

100

WORKLOAD AND ECTS CALCULATION

Activities

Number

Duration (hour)

Total Work Load

Course Duration (x14)

30

2

60

Laboratory

0

0

0

Application

17

1

17

Specific practical training

0

0

0

Field activities

0

0

0

Study Hours Out of Class (Preliminary work, reinforcement, ect)

15

2

30

Presentation / Seminar Preparation

0

0

0

Project

0

0

0

Homework assignment

0

0

0

Preparation for midtermexams

3

2

6

Midterms (Study duration)

3

1

3

Preparation for final exam

1

2

2

Final Exam (Study duration)

1

2

2

Total Workload

120

Matrix Of The Course Learning Outcomes Versus Program Outcomes

D.9. Key Learning Outcomes Contrubition level*
1 2 3 4 5

Explains the basic structure, development and physiological functioning of the body at the level of molecules, cells, tissues, organs and systems.

X

Defines the causes of diseases, mechanisms of occurrence and changes in affected organs with information based on scientific data.

 X

Evaluates and applies the principles of diagnosis, treatment, prevention and rehabilitation of diseases and epidemiology and reduction of common diseases in the community.

Evaluate national and international health systems in the context of health policies, finance and administration.

Know the research processes that constitute the basis of medical knowledge and have the knowledge of foreign language to follow the developments in this field.

Takes a medical history from the patient and, if necessary, from his relatives.

 X

Performs physical examination of patients, evaluates clinical, laboratory and radiological and findings of common diseases and applies diagnosis and treatment processes using appropriate process steps.

 X

Recognizes life-threatening situations, makes appropriate first treatment and directs when necessary.

Performs preventive medical services.

Keeps medical and forensic records in accordance with legal regulations, gives importance to the confidentiality of patient information and prepares and presents patient information when necessary.

Plans and performs the processes for the prevention and health promotion in the context of individuals and community.

Gain the competency to work independently and take responsibility in compulsory situations.

 X

Demonstrate a lifelong learning behavior towards professional and social changes.

X

Fulfills his responsibilities as within the framework of professional values, ethical principles and legislations without discriminating on the basis of race, gender, religion, social and cultural.

Takes part in the teamwork with his colleagues and health care workers for the disease prevention and health promotion.

 X

Follow the scientific and technological developments in medical practice.

X

*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest